Van de Ven Double Halts Everton's Run at New Stadium
Micky van de Ven became the first defender to score twice in a Premier League match for Tottenham since Jan Vertonghen in March 2013.
Match summary
The Spurs defender nods home two times in first half
The home side's Jake O'Brien has goal ruled after video check
Senegalese midfielder scores final goal in 89th minute
This loss is the Merseyside club's first at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Spurs extended their unbeaten run in away games in the Premier League and delivered Everton their first defeat at their new home.
The Toffees were unbeaten in their five previous fixtures at their new ground at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain Van de Ven pounced twice from corners in the opening 45 minutes to put their strong form at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - nodded in a third to put the game to bed.
The Everton defender thought he had levelled the tally five minutes after Van de Ven's opener, directing a bullet header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, missed a number of opportunities, while the Italian goalkeeper made a succession of fine stops to ensure Tottenham went five away games without defeat in the English top flight.
But the video assistant referee intervened, advising the match official to check the goal on the screen and the referee ruled that the winger and the attacker were in an illegal position and had interfered with the Tottenham goalkeeper.
The win moves Thomas Frank's side into third place in the division, five points off local foes and table-toppers Arsenal.
The Merseyside club remain 14th and are six points ahead of the relegation zone.
Tottenham analysis: Van de Ven fulfils duties at both ends of pitch
After a uninspiring weekday display in the Champions League against Monaco, where they mustered a mere attempts on target, the manager opted for Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The new arrival was failed to influence the game before being substituted for Richarlison after 60 minutes on the field, but it turns out he wasn't needed in the end.
Centre-back the Dutchman transformed into an offensive threat to be feared.
Tottenham's first goal came from a well-worked corner routine, with the midfielder directing the ball back across the six-yard box for an free Van de Ven to head home.
And Ven de Ven - stepping up as skipper in the Argentine's absence - notched his second in first-half stoppage time as he rose above Jordan Pickford to nod in.
The Dutchman was equally outstanding in defensive duties, partnering effectively with Kevin Danso as the duo dealt superbly with the numerous deliveries thrown their way by Everton.
Toffees breakdown: Toffees lacking striker's instinct
The club's recent stadium had been a fortress, but it appears the novelty may have faded slightly and supporters headed to the gates after the midfielder's final goal for Tottenham.
The break in Everton's winning streak at home will not be a major concern for the manager, but their attacking woes are.
Beto and Thierno Barry - the Toffees' pair of recognised strikers - had scored only one league goal between them before the weekend's match.
And they were failed to add to that miserable record on a damp and dreary night on Merseyside.
Beto's performance was summed up when he opted to bicycle-kick a golden opportunity from near the goal, even with having room and opportunity to reposition for a more conventional shot that would have tested the keeper.
The substitute, too, failed to influence the game after replacing Beto in the 65th minute.
It wasn't for a shortage of opportunity. The majority of Everton's attacks came through the winger and the forward, who relentlessly delivered dangerous crosses into the Tottenham box.
Upcoming fixtures for these two sides?
The Toffees: Moyes' men head to Sunderland in the top flight on Monday, 3 November at 8 PM.
Spurs: Spurs go to St James' Park on Wednesday, 29 October for their fourth-round League Cup match against the Magpies.